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- Title
Accelerated discovery via a whole-cell model.
- Authors
Sanghvi, Jayodita C; Regot, Sergi; Carrasco, Silvia; Karr, Jonathan R; Gutschow, Miriam V; Bolival, Benjamin; Covert, Markus W
- Abstract
To test the promise of whole-cell modeling to facilitate scientific inquiry, we compared growth rates simulated in a whole-cell model with experimental measurements for all viable single-gene disruption Mycoplasma genitalium strains. Discrepancies between simulations and experiments led to predictions about kinetic parameters of specific enzymes that we subsequently validated. These findings represent, to our knowledge, the first application of whole-cell modeling to accelerate biological discovery.
- Subjects
CYTOLOGY; DEVELOPMENTAL biology; GENOMES; MYCOPLASMA; BIOLOGICAL research; COMPARATIVE studies
- Publication
Nature Methods, 2013, Vol 10, Issue 12, p1192
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.2724