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- Title
The author file: Rolf Zeller and Javier Lopez-Rios.
- Authors
Baker, Monya
- Abstract
The article focuses on the conditional knockout by homologous recombination approach adopted by scientists, Marco Osterwalder, Javier Lopez-Rios and Rolf Zeller, to study the Hand2 gene essential for heart and limb development. It states that the conventional homologous recombination approach takes several months for creating a mouse with a new version of gene. It describes how scientists used the idea that some sites encoded by Hand2 conditional knockout remain even after the gene is deleted.
- Subjects
GENES; GENETIC recombination; GENETIC engineering; OSTERWALDER, Marco; LOPEZ-Rios, Javier
- Publication
Nature Methods, 2010, Vol 7, Issue 11, p861
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth1110-861