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- Title
High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice.
- Authors
Yuzaburo Uetake; Hitoshi Ikeda; Rie Irie; Kazuaki Tejima; Hiromitsu Matsui; Sayoko Ogura; Hong Wang; ShengYu Mu; Daigoro Hirohama; Katsuyuki Ando; Tatsuya Sawamura; Yutaka Yatomi; Toshiro Fujita; Tatsuo Shimosawa
- Abstract
Background: It is widely known that salt is an accelerating factor for the progression of metabolic syndrome and causes cardiovascular diseases most likely due to its pro-oxidant properties. We hypothesized that excessive salt intake also facilitates the development of nonalcoholic steatohepatitis (NASH) which is frequently associated with metabolic syndrome. Methods: We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice. Results: High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride accumulation. Additionally a high-salt and high-fat diet stimulated oxidative stress production and inflammatory reaction to a greater extent than did a high-fat diet in the liver of LOX-1 transgenic/apoE knockout mice. Conclusions: We demonstrated that high-salt diet exacerbated NASH in high-fat diet-fed LOX-1 transgenic /apoE knockout mice and that this effect was associated with the stimulation of oxidative and inflammatory processes; this is the first study to suggest the important role of excessive salt intake in the development of NASH.
- Subjects
LIVER; FATTY degeneration; FIBROSIS; HIGH-fat diet; HIGH-salt diet; INFLAMMATION; OXIDATIVE stress; LABORATORY mice
- Publication
Lipids in Health & Disease, 2015, Vol 14, Issue 1, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/s12944-015-0002-9