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- Title
Inflammation and impaired endothelium-dependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results.
- Authors
Mrizak, Ines; Arfa, Amel; Fekih, Mariem; Debbabi, Haythem; Bouslema, Ali; Boumaiza, Imen; Zaouali, Monia; Khan, Naim A.; Tabka, Zouhair
- Abstract
Background: To evaluate whether abnormal endothelial function, a common finding in gestational diabetes mellitus (GDM) pregnancies, can be explained by inflammatory cytokines. Methods: Forearm skin blood flow (FSBF), into response to acetylcholine (Ach) (endothelium-dependent vasodilatation), were measured in 24 pregnant control subjects and 28 gestational diabetes mellitus (GDM) women, in the third trimester of gestation. A fasting glycemic and lipidic panel was obtained, and inflammatory cytokines (TNF-α and IL-6) and adiponectin were also determined. Results: FSBF is significantly reduced in GDM group compared with control subjects (344.59 ± 57.791 vs.176.38 ± 108.52, P < 0.05). Among all subjects, FSBF showed a strong negative correlation with TNF-α and IL-6 (r = -0.426, P < 0.0001 and r = -0.564, P < 0.0001, respectively) and positive correlation with adiponectin (r = 0.468, P < 0.0001). Conclusions: Endothelial function, an early marker of macrovascular disease, is present in non-obese pregnancies complicated by GDM. This alteration seems to be directly related to inflammatory status, which may represent a patho-physiological link between GDM and type 2 diabetes and, later on, metabolic syndrome.
- Subjects
GESTATIONAL diabetes; ENDOTHELIUM; ENDOTHELINS; VASODILATION; ADIPONECTIN; THIRD trimester of pregnancy; PATHOLOGICAL physiology
- Publication
Lipids in Health & Disease, 2013, Vol 12, Issue 1, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/1476-511X-12-93