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- Title
Title: efficacy of intravitreal dexamethasone implant on hard exudate in diabetic macular edema.
- Authors
Yoon, Chang Ki; Sagong, Min; Shin, Jae Pil; Lee, Sang Joon; Lee, Joo Eun; Lee, Ji Eun; Chung, Inyoung; Jeong, Woo Jin; Pak, Kang Yeun; Kim, Hyun Woong
- Abstract
<bold>Background: </bold>To investigate the effect of intravitreal dexamethasone implant (DEX implant) on hard exudate (HE) accompanying diabetic macular edema (DME).<bold>Methods: </bold>This study was a non-comparative non-randomized 1-year prospective interventional study. Patients with DME and HE were treated using DEX implant two or three times. Color fundus photography and optical coherence tomography (OCT) were performed at every visit. HE area was measured semi-automatically from the fundus photographs.<bold>Results: </bold>Thirty-five patients completed the study. Eleven patients (31.4%) received two injections, while the remaining received three times. HE area (primary outcome) significantly decreased from 1.404±2.094 mm2 (baseline) to 0.212±0.592 mm2 (last visit), which was 24% of the baseline HE area (P<0.001). HE1500 (HE within 1500 μm from the fovea) area also decreased significantly from 0.382±0.467 mm2 to 0.066±0.126 mm2 (P<0.001). Furthermore, anaverage best corrected visual acuity (BCVA) improvement of 4.4 Early Treatment Diabetic Retinopathy Study (ETDRS) letters was observed (from 49.9±18.3 to 54.3±20.4 letters) (P= 0.008). Central macular thickness (CMT) decreased from 455.8±23.6 μm to 366.8±31.1 μm (P=0.009). Repetitive measurements for entire study duration was analyzed using generalized estimating equations (GEE), where BCVA was related to age, CMT, and HE1500 area in multivariate analyses.<bold>Conclusion: </bold>DEX implant could reduce and suppress HE in DME for one year with two or three injections. And centrally located HE area (HE1500 area) is related to vision.<bold>Trial Registration: </bold>ClinicalTrials.gov, NCT02399657 , Registered 26 March 2015.
- Subjects
GENERALIZED estimating equations; OPTICAL coherence tomography; EDEMA; DEXAMETHASONE; DIABETIC retinopathy; THERAPEUTIC use of glucocorticoids; RESEARCH; RETINAL degeneration; INJECTIONS; CLINICAL trials; RESEARCH methodology; DIABETES; CONTROLLED release drugs; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; EXUDATES &; transudates; VISUAL acuity; LONGITUDINAL method; DISEASE complications
- Publication
BMC Ophthalmology, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2415
- Publication type
journal article
- DOI
10.1186/s12886-020-01786-2