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- Title
Distinct but complementary contributions of PPAR isotypes to energy homeostasis.
- Authors
Dubois, Vanessa; Eeckhoute, Jérôme; Lefebvre, Philippe; Staels, Bart
- Abstract
Peroxisome proliferator-activated receptors (PPARs) regulate energy metabolism and hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease. While they share anti-inflammatory activities, the PPAR isotypes distinguish themselves by differential actions on lipid and glucose homeostasis. In this Review we discuss the complementary and distinct metabolic effects of the PPAR isotypes together with the underlying cellular and molecular mechanisms, as well as the synthetic PPAR ligands that are used in the clinic or under development. We highlight the potential of new PPAR ligands with improved efficacy and safety profiles in the treatment of complex metabolic disorders.
- Subjects
METABOLIC syndrome; PEROXISOME proliferator-activated receptors; ENERGY metabolism; TYPE 2 diabetes; MICROCIRCULATION disorders; ANIMALS; FATTY liver
- Publication
Journal of Clinical Investigation, 2017, Vol 127, Issue 4, p1202
- ISSN
0021-9738
- Publication type
journal article
- DOI
10.1172/JCI88894