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- Title
HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44.
- Authors
Frleta, Davor; Ochoa, Carolyn E.; Kramer, Holger B.; Khan, Shaukat Ali; Stacey, Andrea R.; Borrow, Persephone; Kessler, Benedikt M.; Haynes, Barton F.; Bhardwaj, Nina
- Abstract
Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function. We derived immature DCs from healthy donor peripheral blood monocytes and treated them with plasma from uninfected control donors and donors with acute HIV-1 infections. We found that the plasma from patients with HIV specifically inhibited DC function. This suppression was mediated by elevated apoptotic microparticles derived from dying cells during acute HIV-1 infection. Apoptotic microparticles bound to and inhibited DCs through the hyaluronate receptor CD44. These data suggest that targeting this CD44-mediated inhibition by apoptotic microparticles could be a novel strategy to potentiate DC activation of HIV-specific immunity.
- Subjects
HIV infections; APOPTOSIS; IMMUNOLOGIC diseases; CD44 antigen; MONOCYTES; BLOOD plasma
- Publication
Journal of Clinical Investigation, 2012, Vol 122, Issue 12, p4685
- ISSN
0021-9738
- Publication type
Article
- DOI
10.1172/JCI64439