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- Title
Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil.
- Authors
de Menezes, Mariane Talon; Moreira, Filipe Romero Rebello; Whittaker, Charles; Santos, Franciele Martins; Queiroz, Daniel Costa; Geddes, Victor; Fonseca, Paula Luize Camargos; de Jesus, Jaqueline Góes; Mendes-Oliveira, Franciane; Reis-Souza, Valquíria; Santos, Bibiana; Zauli, Danielle Alves Gomes; de Lima, Aline Brito; de Brito Mendonça, Cristiane; Alvim, Luige Biciati; do Prado Silva, Joice; Malta, Frederico Scott Varella; de Souza Ferreira, Alessandro Clayton; Faria, Nuno R.; Sabino, Ester Cerdeira
- Abstract
Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG.
- Subjects
MINAS Gerais (Brazil); BRAZIL; BELO Horizonte (Brazil); SARS-CoV-2; SARS-CoV-2 Omicron variant; COVID-19; PLANT viruses
- Publication
Viruses (1999-4915), 2023, Vol 15, Issue 2, p585
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v15020585