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- Title
Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting‐Group‐Free Synthesis of Sulfonamides.
- Authors
Zhersh, Sergey A.; Blahun, Oleksandr P.; Sadkova, Iryna V.; Tolmachev, Andrey A.; Moroz, Yurii S.; Mykhailiuk, Pavel K.
- Abstract
Abstract: Cyclic saturated aminosulfonyl fluorides were synthesized as their HCl salts. The compounds were found to be stable upon storage and could be used for the protecting‐group‐free synthesis of sulfonamides. In the presence of the −SO2F group, the nitrogen atom could be modified by means of acylation, arylation, or reductive amination to give products that have high potential for the synthesis of bioactive compounds.
- Subjects
FLUORIDES; SULFONAMIDES; ORGANIC synthesis; HYDROGEN chloride; ACYLATION
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 33, p8343
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201801140