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- Title
Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework.
- Authors
Sun, Raymond Wai ‐ Yin; Zhang, Ming; Li, Dan; Zhang, Zhi ‐ Feng; Cai, Hong; Li, Mian; Xian, Yue ‐ Jiao; Ng, Seik Weng; Wong, Alice Sze ‐ Tsai
- Abstract
A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.
- Subjects
PYRROLIDINE; CANCER cells; METAL-organic frameworks; CARBENES; DITHIOCARBAMATES
- Publication
Chemistry - A European Journal, 2015, Vol 21, Issue 51, p18534
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201503656