We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Modulating DNA configuration by interfacial traction: an elastic rod model to characterize DNA folding and unfolding.
- Authors
Huang, Zaixing
- Abstract
a continuum model of DNA, a thin elastic rod subjected to interfacial interactions is used to investigate the equilibrium configuration of DNA in intracellular solution. The interfacial traction between the rod and the solution environment is derived in detail. Kirchhoff's theory of elastic rods is used to analyze the equilibrium configuration of a DNA segment under the action of the interfacial traction. The influences of the interfacial energy factor and bending stiffness on the toroidal spool formation of the DNA segment are discussed. The results show that the equilibrium configuration of DNA is mainly determined by competition between the interfacial energy and elastic strain energy of the DNA itself, and the interfacial traction is one of the forces that drives DNA folding and unfolding.
- Subjects
KIRCHHOFF'S theory of diffraction; DNA; PROTEIN folding; MATHEMATICAL models; STIFFNESS (Mechanics); PHYSIOLOGICAL stress; ELASTIC rods &; wires
- Publication
Journal of Biological Physics, 2011, Vol 37, Issue 1, p79
- ISSN
0092-0606
- Publication type
Article
- DOI
10.1007/s10867-010-9200-x