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- Title
Immunological status of chronically exposed persons with increased level of TCR mutations.
- Authors
Akleyev, A. A.; Blinova, E. A.; Dolgushin, Ilya I.
- Abstract
Dose- and dose rate-dependent increase in the number of СD3+СD16+CD56+-lymphocytes and lysosomal activity of neutrophils was noted in peripheral blood of the Techa riverside residents with increased level of TCR gene-mutated T lymphocytes long after chronic exposure of predominantly red bone marrow (mean exposure dose was 0.89 ± 0.09 Gy, individual dose range was 0.09-1.96 Gy). The performed analysis showed that the above-mentioned immunological changes could be a response to an increase in the frequency of mutations (TCR mutations in particular) in the cells of exposed individuals.
- Subjects
T cell receptors; GENETIC mutation; T cells; BONE marrow; NEUTROPHILS
- Publication
Radiation & Environmental Biophysics, 2019, Vol 58, Issue 1, p81
- ISSN
0301-634X
- Publication type
Article
- DOI
10.1007/s00411-018-0766-1