We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Understanding the Potential Role of Nanotechnology in Liver Fibrosis: A Paradigm in Therapeutics.
- Authors
Singh, Sukhbir; Sharma, Neelam; Shukla, Saurabh; Behl, Tapan; Gupta, Sumeet; Anwer, Md. Khalid; Vargas-De-La-Cruz, Celia; Bungau, Simona Gabriela; Brisc, Cristina
- Abstract
The liver is a vital organ that plays a crucial role in the physiological operation of the human body. The liver controls the body's detoxification processes as well as the storage and breakdown of red blood cells, plasma protein and hormone production, and red blood cell destruction; therefore, it is vulnerable to their harmful effects, making it more prone to illness. The most frequent complications of chronic liver conditions include cirrhosis, fatty liver, liver fibrosis, hepatitis, and illnesses brought on by alcohol and drugs. Hepatic fibrosis involves the activation of hepatic stellate cells to cause persistent liver damage through the accumulation of cytosolic matrix proteins. The purpose of this review is to educate a concise discussion of the epidemiology of chronic liver disease, the pathogenesis and pathophysiology of liver fibrosis, the symptoms of liver fibrosis progression and regression, the clinical evaluation of liver fibrosis and the research into nanotechnology-based synthetic and herbal treatments for the liver fibrosis is summarized in this article. The herbal remedies summarized in this review article include epigallocathechin-3-gallate, silymarin, oxymatrine, curcumin, tetrandrine, glycyrrhetinic acid, salvianolic acid, plumbagin, Scutellaria baicalnsis Georgi, astragalosides, hawthorn extract, and andrographolides.
- Subjects
HEPATIC fibrosis; ERYTHROCYTES; LIVER cells; THERAPEUTICS; FATTY liver; HEMORHEOLOGY
- Publication
Molecules, 2023, Vol 28, Issue 6, p2811
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28062811