We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Propil Tiyourasil (PTU) ve L-Tiroksin ile Oluşturulan Deneysel Hipo- ve Hipertiroidizm Erişkin Sıçanların Hipokampüsünde Doku Lipid Peroksidasyonu, Glutatiyon ve Antioksidan Enzim Düzeyleri Üzerine Araştırmalar.
- Authors
LİMAN, Bilal Cem; LİMAN, Narin; TEKELİ, Muhammed Yasin; ERGEN, Ergül; KAVRAAL, Ural Kemal
- Abstract
Objective: This study aimed to explore the effect of experimental hypo- and hyperthyroidism on the lipid peroxidation and glutathione levels, and the activities of antioxidant system in the rat hippocampus. Material and Methods: The study included 72 adult male Wistar albino rats which were grouped as follows: (1) control group (2) hypothyroidism group: induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 4 weeks; (3) hyperthyroidism group: induced by 4-week thyroxine injection (0.3 mg/kg/day). The levels of lipid peroxidation, glutathione (GSH), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) in the hippocampus of rats with hypo- and hyperthyroidism were examined using ELISA techniques. Conclusion: It can be said that TH disorder may affect cognitive performance by causing some changes in the antioxidant defense system of the hippocampus.
- Subjects
HIPPOCAMPUS physiology; GLUTATHIONE; EXPERIMENTAL design; HORMONE antagonists; THYROID hormones; HYPOTHYROIDISM; THYROXINE; HYPERTHYROIDISM; ANIMAL experimentation; ANTIOXIDANTS; METABOLISM; RATS; ENZYMES; ENZYME-linked immunosorbent assay; LIPID peroxidation (Biology)
- Publication
Balikesir Health Sciences Journal / Balıkesir Sağlık Bilimleri Dergisi, 2022, Vol 11, p22
- ISSN
2146-9601
- Publication type
Article
- DOI
10.53424/balikesirsbd.1149397