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- Title
USE OF RAT GRIMACE SCALE IN PAIN RESEARCH.
- Authors
Zhantleuova, A. K.; Karimova, A. S.; Davletov, B. A.
- Abstract
Since its introduction in 2011, the Rat Grimace Scale (RGS) has proven to be a valuable tool for pain assessment in preclinical studies. This scale includes the assessment of four functional units to quantify pain responses in rats. By observing and assessing changes such as orbital tightening, nose/cheek flattening, ear changes, whisker change researchers can objectively assess the severity of pain experienced by animals. In our article, we offer an overview of a various studies applying this method across surgical and postoperative pain models, inflammatory pain models, orthodontic and orofacial pain models, neuropathic pain models, and others. This study specifically investigates the effectiveness of the RGS in assessing pain in rats, with a particular focus on a nitroglycerin-induced migraine model. The article underscores the humane and non-invasive nature of the RGS, aligning with current ethical standards in animal research. Additionally, it explores the potential application of the RGS across diverse disciplines, including neuroscience, pharmacology, and veterinary medicine. The study also addresses limitations and biases in the current pain assessment methods, proposing future research directions to enhance accuracy and ethical practices in animal pain research. The development of an automated RGS system capable of identifying facial action units in rat images and predicting RGS scores has become imperative to to reduce the labor intensity of the image acquisition and scoring process.
- Subjects
PAIN; MIGRAINE; NITROGLYCERIN; POSTOPERATIVE pain; RATS
- Publication
Experimental Biology (1563-0218), 2024, Vol 98, Issue 1, p154
- ISSN
1563-0218
- Publication type
Article
- DOI
10.26577/eb.2024.v98.i1.013