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- Title
Isolation and Evaluation of Anti-Mycobacterial Activity of Alkaloid Compounds from Marine Invertebrate Sponge Haliclona sp.
- Authors
Maarisit, Wilmar; Untu, Sonny D.; Lengkey, Yessie K.; Mongi, Jeane; Kanter, Jabes W.; Pareta, Douglas N.; Sambou, Chistel N.; Tumbel, Silvana L.; Montolalu, Friska M.; Korua, Sandra A.; Tulungen, Franky R.
- Abstract
Marine invertebrate sponges are a rich source of new bioactive substances. The objective of this investigation was to isolate the anti-mycobacterium bioactive compounds from sponge Haliclona sp. A new alkaloid (1) was obtained through bioassay-guided purification together with eight previously known substances, including cyclostellettamines A (5), B (6), C (7), E (8), and F (9) and the haliclocyclamines A (2), B (3), and C. The structures of 1-9 were established applying spectroscopic analysis, including 1D NMR (1H and 13C-NMR), 2D NMR (HMQC, HMBC, 1H-1H COSY), mass spectroscopy, IR, and UV. Furthermore, the findings revealed that the compounds exhibited inhibitory activity against Mycobacterium smegmatis at 10 µg/disc.
- Subjects
MARINE invertebrates; BIOACTIVE compounds; HALICLONA; MYCOBACTERIUM; BIOLOGICAL assay
- Publication
Tropical Journal of Natural Product Research, 2022, Vol 6, Issue 10, p1622
- ISSN
2616-0684
- Publication type
Article
- DOI
10.26538/tjnpr/v6i10.10