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- Title
A competent review of computer imitations of pharmacokinetic and pharmacodynamic arrangements.
- Authors
Ahad, H. A.; Kumar, G. A.; Chinthaginjala, H.; Tarun, K.; Reddy, G. G.
- Abstract
Computer simulation in the field of pharmacokinetics and pharmacodynamics or in silico modelling is the need of the hour in the biomedical field. A computer simulation (CS) is a program run on a computer that uses step-by-step methods to explore the approximate behaviour of a mathematical model. The mathematical models enable the computational simulation of real-world systems. As the program is executed, the mathematical dynamics that arise constitute an analogue of the real-world system's behaviour. Computer simulations thus offer a means of quantitatively and qualitatively simulating, analysing, and visualising complex biological processes. Furthermore, in silico studies may help facilitate the research process by embedding ease and efficiency through computational simulations. This article explores the importance of computer programs for the simulation of in silico experiments with the help of mathematical descriptions or models. The current review summarises the various CS models for different drugs with their outcomes. The major challenge that seems to emerge is the need for quantitative, testable, and validated frameworks for the joint analysis of large data sets available in disparate formats and focused on different biological scales. The solution(s) to this problem will require a diverse set of disciplines, including not only biology and pharmacology but also (bio) engineering, computer science, (applied) mathematics and physics, and (bio) statistics. The study summarises and gives a brief review of recent biocomputation developments that are potentially relevant to drug development.
- Subjects
PHARMACOKINETICS; BIG data; COMPUTER simulation; CONTINUOUS time models; COMPUTER software
- Publication
SA Pharmaceutical Journal Incorporating Pharmacy Management, 2023, Vol 90, Issue 1, p29
- ISSN
2221-5875
- Publication type
Article