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- Title
Chemokine receptor CXCR4–dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells.
- Authors
Dar, Ayelet; Goichberg, Polina; Shinder, Vera; Kalinkovich, Alexander; Kollet, Orit; Netzer, Neta; Margalit, Raanan; Zsak, Marion; Nagler, Arnon; Hardan, Izhar; Resnick, Igor; Rot, Antal; Lapidot, Tsvee
- Abstract
Regulation of the availability of chemokine SDF-1 (CXCL12) in bone marrow is still not fully understood. Here we describe a unique function for the chemokine receptor CXCR4 expressed on bone marrow endothelial cells, which efficiently internalize circulating SDF-1, resulting in its translocation into the bone marrow. Translocated SDF-1 increased the homing of transplanted human CD34+ hematopoietic progenitors to the bone marrow. The chemokine transporter function of CXCR4 was a characteristic of endothelial and stromal cells but not of hematopoietic cells. Thus, chemokine translocation across the blood–bone marrow barrier allows effective transfer of functional SDF-1 from the periphery to the stem cell niche in the bone marrow during both homeostasis and 'alarm' situations.
- Subjects
CHEMOKINES; INFLAMMATORY mediators; BONE marrow; ENDOTHELIAL seeding; VASCULAR grafts; PHYSIOLOGICAL control systems; IMMUNE system
- Publication
Nature Immunology, 2005, Vol 6, Issue 10, p1038
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1251