We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impairment of immunological memory in the absence of MHC despite survival of memory T cells.
- Authors
Kassiotis, George; Garcia, Sylvie; Simpson, Elizabeth; Stockinger, Brigitta
- Abstract
The mechanisms by which immunological memory is maintained after infection or vaccination are still a matter of debate. Long-term survival of memory T cells does not require major histocompatibility complex (MHC) contact. We show here that compared with memory CD4+ T cells that maintain contact with MHC class II, memory CD4+ T cells deprived of MHC class II contact show distinct functional defects upon antigen re-encounter. Thus, in contrast to their survival, maintenance of the typical quality of memory T cells crucially depends on MHC-derived signals.
- Subjects
IMMUNOLOGIC memory; MAJOR histocompatibility complex; T cells; IMMUNOLOGY
- Publication
Nature Immunology, 2002, Vol 3, Issue 3, p244
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni766