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- Title
Does Serotonin Play a Role in Epilepsy?
- Authors
Theodore, William H.
- Abstract
Studies in experimental models have suggested a potential role for serotonergic transmission in epilepsy, and interest in this research has been increased by the development of positron emission tomography (PET) ligands that can be used to study 5-hydroxytryptamine (5-HT) receptors and transporters. The serotonergic system is very complex. At least 13 distinct G protein–coupled 5-HT receptors and one ligand-gated ion channel receptor (5-HT[sub 3] ) are divided into seven distinct classes (5-HT[sub 1] to 5-HT[sub 7] ) (1). The receptors vary widely in their distribution and effects, innervating vascular structures and gut smooth muscle as well as neuronal tissue. Several receptor subtypes may be relevant to epilepsy.
- Subjects
SEROTONINERGIC mechanisms; EPILEPSY; LIGANDS (Biochemistry); SYMPATHETIC nervous system; BRAIN diseases
- Publication
Epilepsy Currents, 2003, Vol 3, Issue 5, p173
- ISSN
1535-7597
- Publication type
Article
- DOI
10.1046/j.1535-7597.2003.03508.x