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- Title
Ameliorative effects of ark clams (Scapharca subcrenata and Tegillarca granosa) on endothelial dysfunction induced by a high-fat diet.
- Authors
Chanmuang, Saoraya; Meemalai, Orawan; Promyo, Kitipong; Park, Kyung-Hee; Pongworn, Suthipong; Gong, Dal-Seong; Oak, Min-Ho; Cho, Jeong-Yong; Kang, Seong-Gook; Ham, Kyung-Sik
- Abstract
Endothelial dysfunction is directly involved in consequence of various metabolic syndromes such as diabetes and hypertension. In this study, we investigated the preventive effects of two ark clams [ark shell (AS, Scapharca subcrenata) and granular ark (GA, Tegillarca granosa)] on endothelial dysfunction induced by a high-fat diet. Wistar rats were divided into four groups as follows: control (normal diet), HF (high-fat diet), AS (high-fat diet + 5% AS powder), and GA (high-fat diet + 5% GA powder) for 12 weeks. AS and GA diets enhanced vascular reactivity of the rat thoracic aorta and significantly increased expression levels of vascular relaxation-related proteins (p-Akt-ser473 and p-eNOS-ser1177). Ark clam supplement reduced endothelin-1 expression level, as compared to the HF group. Additionally, AS and GA showed a trend of improving insulin sensitivity compared to HF. Our results suggest that AS and GA enhance vascular reactivity and ameliorated endothelial dysfunction induced by a high-fat diet.
- Subjects
HIGH-fat diet; ENDOTHELIUM diseases; CLAMS; THORACIC aorta; INSULIN resistance
- Publication
Applied Biological Chemistry, 2020, Vol 63, Issue 1, p1
- ISSN
2468-0834
- Publication type
Article
- DOI
10.1186/s13765-020-00556-4