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- Title
Seronegative Adult Autoimmune Enteropathy in a Patient With Rheumatoid Arthritis.
- Authors
Lundholm, Michelle D.; Wanta, Kaitlin; Xianzhong Ding; Palmera, Lena; Abegunde, Ayokunle T.
- Abstract
Autoimmune enteropathy is a rare disorder of the immune system. We present a 75-year-old woman with rheumatoid arthritis who presented with 4 months of intractable vomiting, diarrhea, and unexplained weight loss. Initial workup was negative for infection and celiac disease, but her symptoms progressed. Repeat esophagogastroduodenoscopy showed duodenal scalloping and friability. Biopsies of the duodenum and terminal ileum showed glandular destruction, epithelial apoptosis, and goblet cell depletion. Colonoscopic examination was normal, and random colon biopsies did not show evidence of microscopic colitis. She was diagnosed with autoimmune enteropathy, and treatment consisted of an extended corticosteroid taper, with the resolution of symptoms.
- Subjects
AUTOIMMUNE disease diagnosis; ADRENOCORTICAL hormones; APOPTOSIS; AUTOIMMUNE diseases; BIOPSY; DUODENUM; ILEUM; RHEUMATOID arthritis; DIGESTIVE system endoscopic surgery; HIV seronegativity
- Publication
ACG Case Reports Journal, 2019, Vol 6, Issue 10, p1
- ISSN
2326-3253
- Publication type
Article
- DOI
10.14309/crj.0000000000000239