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- Title
Monoklonale Antikörper bei Lymphomen.
- Authors
Hallek, Michael; Wendtner, Clemens-Martin; Fingerle-Rowson, Günter; Fischer, Kirsten; Goede, Valentin; Schweighofer, Carmen; Fink, Anna-Maria; Elter, Thomas; Kofler, David; Busch, Raymonde; Emmerich, Bertold; Eichhorst, Barbara
- Abstract
The article focuses on the role of monoclonal antibodies in the treatment of chronic lymphocytic leukemia (CLL). The main focus is on the combined use of chemotherapy with monoclonal antibodies (commonly called chemo- immunotherapy) in CLL, that is, fludarabine, rituximab and alemtuzumab-based chemo-immunotherapy. Fludarabine has been evaluated in a variety of combination regimens. One of the most promising and most thoroughly studied combinations is fludarabine plus cyclophosphamide. Rituximab, an anti-CD20 monoclonal antibody, has only recently provoked interest for the treatment of CLL. Alemtuzumab is a recombinant, fully humanized, monoclonal antibody against the CD52 antigen.
- Subjects
CHRONIC lymphocytic leukemia treatment; MONOCLONAL antibodies; IMMUNOTHERAPY; CD antigens; FLUDARABINE; RITUXIMAB
- Publication
Drug Research / Arzneimittel-Forschung (Editio Cantor Verlag fur Medizin und Naturwissenschaften), 2005, Vol 55, Issue 11, p704
- ISSN
0004-4172
- Publication type
Article