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- Title
98例β-内酰胺类抗菌药物致不良反应.
- Authors
杨茵梅; 李坤浪; 钟伟章; 李文胜
- Abstract
OBJECTIVE:To investigate the status and characteristics of 98 cases of adverse drug reactions ( ADR) induced by β-lactam antibiotics in Gaozhou People's Hospital ( hereinafter referred to as"our hospital") , so as to provide reference for the rational drug use in clinic .METHODS:Statistical analysis was conducted on 98 cases of ADR induced by β-lactam antibiotics collected by our hospital during 2011-2015 in terms of the clinical medication , route of administration, type of ADR, clinical manifestation and prognosis , etc..RESULTS: Of the 98 cases, the ratio of patients >50 years old took the lead, accounting for 48.98%(48 cases); followed by ≤12 years old(29 cases, 29.59%) .And the ratio of number of ADR cases induced by intravenous infusion dominated the first place , accounting for 68.37%(67 cases);and the ratio of number of ADR cases induced by cephalosporins antibiotics was 62.24%( 67 cases ) , higher than that of penicillins .ADR mainly involved skin and its appendages , respiratory system .There were 75 cases of patients cured , 18 improved , 4 cases of sequela and 1 case of death .CONCLUSIONS:ADR induced by β-lactam antibiotics often concentrate on the special crowd with intravenous medication , mainly involved skin and its appendages , respiratory system .Although the cure rate is high , there are still some cases of sequela and death due to lack of timely and properly treatment .Therefore , it is necessary for the clinic to attach enough importance to the application of β-lactam antibiotics , timely find out the ADR and actively take effective measures to reduce or avoid the occurrence of ADR , so as to ensure the medication safety in patients .
- Publication
Evaluation & Analysis of Drug-Use in Hospitals of China, 2016, Vol 16, Issue 7, p994
- ISSN
1672-2124
- Publication type
Article
- DOI
10.14009/j.Lssn.1672-2124.2016.07.048