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- Title
Sugammadex: Pharmacometrics, Clinical Utility, and Adverse Effects.
- Authors
Swerdlow, Barry; Osborne-Smith, Lisa
- Abstract
Sugammadex has been used clinically since 2008, and it represents the only cyclodextrin neuromuscular blocking reversal agent currently available for patient care. Sugammadex's unique mechanism of action allows it to reverse the efects of aminosteroid neuromuscular blockade rapidly, and pharmacodynamically predictable doses are selected based on quantitative neuromuscular monitoring. The drug has several potential adverse efects, predominantly related to immediate hypersensitivity reactions and bradyarrhythmias, and it can be costly. Overall, when employed appropriately, it represents an efficacious addition to the perioperative pharmaceutical armamentarium with significant utility.
- Subjects
ROCURONIUM bromide; DRUG efficacy; NEUROMUSCULAR blockade; DRUG interactions; SUGAMMADEX; NEUROMUSCULAR blocking agents
- Publication
AANA Journal, 2022, Vol 90, Issue 2, p133
- ISSN
0094-6354
- Publication type
Article