We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acute HIV infection presenting with painful swallowing and esophageal ulcers.
- Authors
Rabeneck, L; Popovic, M; Gartner, S; McLean, D M; McLeod, W A; Read, E; Wong, K K; Boyko, W J
- Abstract
We describe an acute human immunodeficiency virus (HIV) infection in 16 homosexual men who presented with painful swallowing (odynophagia). Eleven men had a maculopapular rash and 3 had palatal ulcers. At esophagogastroduodenoscopy (endoscopy), multiple discrete esophageal ulcers measuring 0.3 to 1.5 cm in diameter were observed. Electron microscopy of biopsy specimens taken from the ulcer margins in 8 men revealed viral particles 120 to 160 nm in diameter whose morphologic characteristics were those of retroviruses. Human immunodeficiency virus seroconversion was documented in 15 men by Western blot analysis. In 3 men, HIV-1 was isolated from peripheral blood mononuclear cells, in 2 men HIV-1 was isolated from peripheral blood monocytes, and in 1 man HIV-1 was isolated from tissue taken from the margins of the esophageal ulcers. These observations extend our knowledge of the clinical spectrum of acute HIV infection syndromes and suggest that cells in the esophagus are a target for HIV-1 infection.
- Subjects
AIDS complications; AIDS diagnosis; ULCER diagnosis; AIDS; COMPARATIVE studies; DEGLUTITION; DIFFERENTIAL diagnosis; ESOPHAGUS diseases; HIV; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PAIN; RESEARCH; ULCERS; EVALUATION research; ACUTE diseases; LEUKOCYTE count; DIAGNOSIS
- Publication
JAMA: Journal of the American Medical Association, 1990, Vol 263, Issue 17, p2318
- ISSN
0098-7484
- Publication type
journal article
- DOI
10.1001/jama.263.17.2318