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- Title
Utility and Limitations of Addenbrooke's Cognitive Examination-Revised for Detecting Mild Cognitive Impairment in Parkinson's Disease.
- Authors
Komadina, Natalie C.; Terpening, Zoe; Huang, Yue; Halliday, Glenda M.; Naismith, Sharon L.; Lewis, Simon J.G.
- Abstract
Background/Aims: To evaluate the utility of the Addenbrooke's Cognitive Examination-Revised (ACE-R) as a screening tool for mild cognitive impairment in Parkinson's disease (PD-MCI). Methods: PD patients underwent comprehensive neuropsychological and neurological evaluations and ACE-R assessment. Results: The ACE-R was superior to the Mini-Mental State Exam (MMSE) in detecting PD-MCI, with a cutoff score of ≤93 offering a sensitivity of 61% and a specificity of 64%. The utility of the ACE-R in detecting PD-MCI is largely influenced by the fluency sub-domain score, and has optimal discriminability when utilized in patients with lower levels of education (≤12 years of formal schooling). Conclusion: The ACE-R must be used cautiously as a screening tool for PD-MCI, with results being most influenced by its fluency sub-domain score and patient education levels. Copyright © 2011 S. Karger AG, Basel
- Subjects
PARKINSON'S disease diagnosis; RESEARCH methodology evaluation; ANALYSIS of variance; CHI-squared test; COGNITIVE testing; COGNITION disorders; U-statistics; RECEIVER operating characteristic curves
- Publication
Dementia & Geriatric Cognitive Disorders, 2011, Vol 31, Issue 5, p349
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000328165