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- Title
Diagnostic Performance of the Chinese Frontal Assessment Battery in Early Cognitive Impairment in an Asian Population.
- Authors
Chong, M. S.; Lim, W. S.; Chan, S. P.; Feng, L.; Niti, M.; Yap, P.; Yeo, D.; Ng, T.-P.
- Abstract
Background: The Frontal Assessment Battery (FAB) has been shown to be useful in evaluating frontal dysfunction. There is a paucity of studies validating cutoffs in the early cognitive impairment. We aim to validate the Chinese FAB in Asian subjects with mild cognitive impairment (MCI) and early dementia. Methods: Eighty subjects with MCI and mild dementia and 100 cognitively healthy community subjects were studied. ROC analysis was done to determine the Chinese FAB's optimal cutoff scores for age- and education-adjusted subgroups. Results: Chinese FAB scores were significantly lower in early cognitive impairment compared with cognitively normal controls. The optimal cutoff score was 12/13 (sensitivity 92%, specificity 78.7%). A similar cutoff score was obtained following age-adjustment and for subjects with <6 years' education. Of note, the optimal cutoff for subjects with ≥6 years' education was 13/14 (sensitivity 91.8%, specificity 70.3%), an improved diagnostic performance compared to the earlier reported 11/12 cutoff. In comparison, the Mini-Mental Status Examination (MMSE) had lower rule-out accuracy (77% sensitivity, 91.2% specificity). The combination of the Chinese FAB and MMSE was superior to either test in isolation. Conclusion: The education-adjusted Chinese FAB has good diagnostic performance, which can supplement the MMSE in early cognitive impairment evaluation with construct differences observed between the Chinese FAB and MMSE. Copyright © 2011 S. Karger AG, Basel
- Subjects
ASIA; ALZHEIMER'S disease diagnosis; COGNITION disorders; COMPUTER software; NEUROPSYCHOLOGY; NONPARAMETRIC statistics; RESEARCH funding; STATISTICS; U-statistics; DATA analysis; RECEIVER operating characteristic curves; EARLY diagnosis
- Publication
Dementia & Geriatric Cognitive Disorders, 2011, Vol 30, Issue 6, p525
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000321665