We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immune Response to and Gluten Sensitivity.
- Authors
Puccetti, Antonio; Saverino, Daniele; Opri, Roberta; Gabrielli, Oretta; Zanoni, Giovanna; Pelosi, Andrea; Fiore, Piera Filomena; Moretta, Francesca; Lunardi, Claudio; Dolcino, Marzia
- Abstract
Rotavirus is a double-stranded RNA virus belonging to the family of Reoviridae. The virus is transmitted by the faecal-oral route and infects intestinal cells causing gastroenteritis. Rotaviruses are the main cause of severe acute diarrhoea in children less than 5 years of age worldwide. In our previous work we have shown a link between rotavirus infection and celiac disease. Nonceliac gluten sensitivity (NCGS) is emerging as new clinical entity lacking specific diagnostic biomarkers which has been reported to occur in 6-10% of the population. Clinical manifestations include gastrointestinal and/or extraintestinal symptoms which recede with gluten withdrawal. The pathogenesis of the disease is still unknown. Aim of this work is to clarify some aspects of its pathogenesis using a gene array approach. Our results suggest that NCGS may have an autoimmune origin. This is based both on gene expression data (i.e., TH17-interferon signatures) and on the presence of TH17 cells and of serological markers of autoimmunity in NCGS. Our results also indicate a possible involvement of rotavirus infection in the pathogenesis of nonceliac gluten sensitivity similarly to what we have previously shown in celiac disease.
- Subjects
ROTAVIRUSES; IMMUNE response; GASTROENTERITIS; DOUBLE-stranded RNA; GLUTEN allergenicity; GENE expression; INFECTIOUS disease transmission
- Publication
Journal of Immunology Research, 2018, p1
- ISSN
2314-8861
- Publication type
journal article
- DOI
10.1155/2018/9419204