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Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations.
- Published in:
- Angewandte Chemie, 2020, v. 132, n. 34, p. 14589, doi. 10.1002/ange.202003500
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- Article
Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
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- Angewandte Chemie, 2018, v. 130, n. 36, p. 11803, doi. 10.1002/ange.201805187
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- Publication type:
- Article
Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
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- Angewandte Chemie International Edition, 2018, v. 57, n. 36, p. 11629, doi. 10.1002/anie.201805187
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- Publication type:
- Article
Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
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- EMBO Journal, 2001, v. 20, n. 21, p. 5840, doi. 10.1093/emboj/20.21.5840
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- Article
MELK is not necessary for the proliferation of basal-like breast cancer cells.
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- eLife, 2017, p. 1, doi. 10.7554/eLife.26693
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- Publication type:
- Article
SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.
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- International Immunology, 2004, v. 16, n. 5, p. 727, doi. 10.1093/intimm/dxh074
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- Publication type:
- Article
Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.
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- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30258-y
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- Article
Structural Analysis of the Macrocyclic Inhibitor BI‐4020 Binding to EGFR Kinase.
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- ChemMedChem, 2024, v. 19, n. 12, p. 1, doi. 10.1002/cmdc.202300343
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- Article
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
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- Nature Structural & Molecular Biology, 2015, v. 22, n. 9, p. 703, doi. 10.1038/nsmb.3074
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- Article
JAK-cytokine receptor recognition, unboxed.
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- Nature Structural & Molecular Biology, 2014, v. 21, n. 5, p. 431, doi. 10.1038/nsmb.2824
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- Article
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.
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- Nature Structural & Molecular Biology, 2013, v. 20, n. 10, p. 1221, doi. 10.1038/nsmb.2673
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- Publication type:
- Article
Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
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- Nature Structural & Molecular Biology, 2010, v. 17, n. 10, p. 1175, doi. 10.1038/nsmb.1907
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- Publication type:
- Article
Structure of the regulatory domains of the Src-family tyrosine kinase Lck.
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- Nature, 1994, v. 368, n. 6473, p. 764, doi. 10.1038/368764a0
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- Publication type:
- Article
Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck.
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- Nature, 1993, v. 362, n. 6415, p. 87, doi. 10.1038/362087a0
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- Publication type:
- Article
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors.
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- Communications Chemistry, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42004-024-01108-3
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- Publication type:
- Article
The FERM domain: organizing the structure and function of FAK.
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- Nature Reviews Molecular Cell Biology, 2010, v. 11, n. 11, p. 802, doi. 10.1038/nrm2996
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- Article
Publisher Correction: Cryo-EM structure of a RAS/RAF recruitment complex.
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- 2023
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- Correction Notice
Cryo-EM structure of a RAS/RAF recruitment complex.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40299-6
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- Publication type:
- Article
Crystal Structure of a Coiled-Coil Domain from Human ROCK I.
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- PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0018080
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- Publication type:
- Article
Crystal Structure of a Complex between Amino and Carboxy Terminal Fragments of mDia1: Insights into Autoinhibition of Diaphanous-Related Formins.
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- PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012992
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- Publication type:
- Article
Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation.
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- PLoS ONE, 2008, v. 3, n. 11, p. 1, doi. 10.1371/journal.pone.0003800
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- Article
PH domain-mediated autoinhibition and oncogenic activation of Akt.
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- eLife, 2022, p. 1, doi. 10.7554/eLife.80148
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- Article
Structure and regulation of Src family kinases.
- Published in:
- Oncogene, 2004, v. 23, n. 48, p. 7918, doi. 10.1038/sj.onc.1208081
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- Article
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
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- Nature, 2009, v. 462, n. 7276, p. 1070, doi. 10.1038/nature08622
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- Publication type:
- Article
The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease.
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- 2003
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- Publication type:
- journal article
SAP couples Fyn to SLAM immune receptors.
- Published in:
- Nature Cell Biology, 2003, v. 5, n. 2, p. 155, doi. 10.1038/ncb920
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- Publication type:
- Article
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.
- Published in:
- Nature Communications, 2017, v. 8, n. 3, p. 14892, doi. 10.1038/ncomms14892
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- Publication type:
- Article
Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 34, p. 14481, doi. 10.1002/anie.202003500
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- Publication type:
- Article
The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.
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- Developmental Neuroscience, 2020, v. 42, n. 5-6, p. 170, doi. 10.1159/000512976
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- Publication type:
- Article
Crystal Structure of the FERM-SH2 Module of Human Jak2.
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- PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0156218
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- Publication type:
- Article
Structure of a WW domain containing fragment of dystrophin in complex with β-dystroglycan.
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- Nature Structural Biology, 2000, v. 7, n. 8, p. 634, doi. 10.1038/77923
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- Article
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer.
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- NPJ Precision Oncology, 2021, v. 5, n. 1, p. 1, doi. 10.1038/s41698-021-00204-0
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- Publication type:
- Article
Structural basis for negative regulation of hypoxia-inducible factor-1a by CITED2.
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- Nature Structural Biology, 2003, v. 10, n. 7, p. 504, doi. 10.1038/nsb936
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- Publication type:
- Article
Structure of a human Tcf4?β-catenin complex.
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- Nature Structural Biology, 2001, v. 8, n. 12, p. 1053, doi. 10.1038/nsb720
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- Publication type:
- Article
Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
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- Nature Structural Biology, 2001, v. 8, n. 6, p. 499, doi. 10.1038/88556
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- Article
Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium.
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- Nature Structural Biology, 2001, v. 8, n. 3, p. 243, doi. 10.1038/84988
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- Article
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
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- Nature Chemical Biology, 2007, v. 3, n. 4, p. 229, doi. 10.1038/nchembio866
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- Publication type:
- Article
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
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- Nature, 1999, v. 402, n. 6763, p. 29, doi. 10.1038/31000000
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- Publication type:
- Article
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
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- Nature, 1999, v. 398, n. 6722, p. 84, doi. 10.1038/18050
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- Publication type:
- Article
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the...
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- Nature, 1996, v. 379, n. 6562, p. 277, doi. 10.1038/379277a0
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- Publication type:
- Article
A structural perspective on targeting the RTK/Ras/MAP kinase pathway in cancer.
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- Protein Science: A Publication of the Protein Society, 2021, v. 30, n. 8, p. 1535, doi. 10.1002/pro.4125
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- Article