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- Title
Consumption of dietary nuts in midlife and risk of cognitive impairment in late-life: the Singapore Chinese Health Study.
- Authors
Jiang, Yi-Wen; Sheng, Li-Ting; Feng, Lei; Pan, An; Koh, Woon-Puay
- Abstract
Background evidence from prospective studies investigating the association between consumption of nuts in midlife and risk of cognitive impairment in late life is limited. Methods this study analysed data from 16,737 participants in a population-based cohort, the Singapore Chinese Health Study. Intake of nuts was assessed using a validated food-frequency questionnaire at baseline (1993–1998), when participants were 45–74 years old (mean age = 53.5 years). Cognitive function was tested using the Singapore modified Mini-Mental State Examination during the third follow-up visit (2014–2016), when participants were 61–96 years old (mean age = 73.2 years). Cognitive impairment was defined using education-specific cut-off points. Logistic regression models were used to estimate the odds ratio (OR) and the 95% confidence interval (CI) for the association between intake and risk of cognitive impairment. Results cognitive impairment was identified in 2,397 (14.3%) participants. Compared with those who consumed <1 serving/month of nuts, participants who consumed 1–3 servings/month, 1 serving/week and ≥2 servings/week had 12% (95% CI 2–20%), 19% (95% CI 4–31%) and 21% (2–36%) lower risk of cognitive impairment, respectively (P -trend = 0.01). Further adjustment for intake of unsaturated fatty acids attenuated the association to non-significance. Mediation analysis showed that the 50.8% of the association between nuts and risk of cognitive impairment was mediated by the intake of total unsaturated fatty acids (P < 0.001). Conclusion higher intake of nuts in midlife was related to a lower risk of cognitive impairment in late life, which was partly mediated by unsaturated fatty acids.
- Subjects
COGNITION disorder risk factors; UNSATURATED fatty acids; COGNITION disorders; CONFIDENCE intervals; INGESTION; NUTRITIONAL requirements; COGNITION; RISK assessment; PSYCHOLOGICAL tests; QUESTIONNAIRES; DESCRIPTIVE statistics; ODDS ratio; LOGISTIC regression analysis; NUTS; LONGITUDINAL method; SECONDARY analysis; OLD age
- Publication
Age & Ageing, 2021, Vol 50, Issue 4, p1215
- ISSN
0002-0729
- Publication type
Article
- DOI
10.1093/ageing/afaa267