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- Title
Chemiluminescent carbon nanodots for dynamic and guided antibacteria.
- Authors
Han, Jiang-Fan; Lou, Qing; Ding, Zhong-Zheng; Zheng, Guang-Song; Ni, Qing-Chao; Song, Run-Wei; Liu, Kai-Kai; Zang, Jin-Hao; Dong, Lin; Shen, Cheng-Long; Shan, Chong-Xin
- Abstract
Advanced antibacterial technologies are needed to counter the rapid emergence of drug-resistant bacteria. Image-guided therapy is one of the most promising strategies for efficiently and accurately curing bacterial infections. Herein, a chemiluminescence (CL)-dynamic/guided antibacteria (CDGA) with multiple reactive oxygen species (ROS) generation capacity and chemiexcited near-infrared emission has been designed for the precise theranostics of bacterial infection by employing near-infrared emissive carbon nanodots (CDs) and peroxalate as CL fuels. Mechanistically, hydrogen peroxide generated in the bacterial microenvironment can trigger the chemically initiated electron exchange between CDs and energy-riched intermediate originated from the oxidized peroxalate, enabling bacterial induced inflammation imaging. Meanwhile, type I/II photochemical ROS production and type III ultrafast charge transfer from CDs under the self-illumination can inhibit the bacteria proliferation efficiently. The potential clinical utility of CDGA is further demonstrated in bacteria infected mice trauma model. The self-illuminating CDGA exhibits an excellent in vivo imaging quality in early detecting wound infections and internal inflammation caused by bacteria, and further are proven as efficient broad-spectrum antibacterial nanomedicines without drug-resistance, whose sterilizing rate is up to 99.99%. Chemiluminescence-dynamic/guided antibacterial agents with multiple reactive oxygen species generation capacity and chemi-excited near-infrared emission from carbon nanodots have been designed for precise theranostics of bacterial infection.
- Publication
Light: Science & Applications, 2023, Vol 12, Issue 1, p1
- ISSN
2047-7538
- Publication type
Article
- DOI
10.1038/s41377-023-01149-8