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- Title
Peppermint oil and caraway oil in functional dyspepsia — efficacy unaffected by H. pylori.
- Authors
May, B.; Funk, P.; Schneider, B.
- Abstract
Peppermint oil and caraway oil in functional dyspepsia -- efficacy unaffected by H. pylori SIRS, In the December 2000 issue of Alimentary Pharmacology and Therapeutics, we reported the results of our double-blind, placebo-controlled, randomized clinical trial proving the efficacy of PCC (marketed in Germany under the trade name Enteroplant by Dr Willmar Schwabe GmbH & Co., Karlsruhe, and Spitzner Arzneimittelfasbrik GmbH, Ettlingen), a fixed combination of 90 mg peppermint oil (WS 1340) and 50 mg caraway oil (WS 1520) (WS 1340 and WS 1520 are registered trademarks of Dr Willmar Schwabe GmbH & Co., Karlsruhe, Germany), in the treatment of functional dyspepsia.[1] As approximately one-half of patients suffering from functional dyspepsia are infected with Helicobacter pylori,[2' 3] we have investigated the influence of H. pylori status (determined during screening using the rapid urease test with biopsy) on the efficacy of functional dyspepsia treatment with PCC in a post hoc subgroup analysis. The efficacy variables 'intensity of gastric pain', 'sensation of pressure, heaviness and fullness' and 'persistence of functional dyspepsia-related pain' (patients' self-ratings) were assessed for changes between baseline and the end of treatment using continuous visual analogue scales (0, absent/never; 10, extremely severe/constant). Within each treatment group, separate calculations were performed for H. pylori-positive and H. pylori-negative patients. The analyses, based on all 96 randomized patients (PCC, 48; placebo, 48), followed the intention-to-treat principle. In both sub-groups, which revealed comparable base-line characteristics, patients given PCC showed notably larger improvements in all three outcome measures.
- Subjects
PEPPERMINT oil; HELICOBACTER pylori; INDIGESTION
- Publication
Alimentary Pharmacology & Therapeutics, 2003, Vol 17, Issue 7, p975
- ISSN
0269-2813
- Publication type
Academic Journal
- DOI
10.1046/j.1365-2036.2003.01522.x