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- Title
Detectable chromosome X mosaicism in males is rarely tolerated in peripheral leukocytes.
- Authors
Zhou, Weiyin; Lin, Shu-Hong; Khan, Sairah M.; Yeager, Meredith; Chanock, Stephen J.; Machiela, Mitchell J.
- Abstract
Age-related male Y and female X chromosome mosaicism is commonly observed in large population-based studies. To investigate the frequency of male X chromosome mosaicism, we scanned for deviations in chromosome X genotyping array intensity data in a population-based survey of 196,219 UK Biobank men. We detected 12 (0.006%) men with mosaic chromosome X gains ≥ 2 Mb and found no evidence for mosaic chromosome X loss, a level of detection substantially lower than for autosomes or other sex chromosomes. The rarity of chromosome X mosaicism in males relative to females reflects the importance of chromosome X gene dosage for leukocyte function.
- Subjects
X chromosome; Y chromosome; MOSAICISM; GENOTYPES; SEX chromosomes
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-80948-0