We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Developmental differences in the intestinal microbiota of Chinese 1-year-old infants and 4-year-old children.
- Authors
Guo, Min; Miao, Maohua; Wang, Yuezhu; Duan, Mengmeng; Yang, Fen; Chen, Yao; Yuan, Wei; Zheng, Huajun
- Abstract
The microbiota profile of children changes with age. To investigate the differences in the gut microbiota profile of 1- and 4-year-old children, we collected fecal samples and sequenced the V3–V4 hypervariable region of the 16S rRNA gene via high-throughput DNA sequencing. From phylum to species level, the microbiota underwent significant changes with age. The abundance of phyla Proteobacteria and Actinobacteria declined with age, whereas phyla Firmicutes and Bacteroidetes increased with age and dominated the gut microbiota of 4-year-olds. The intestinal environment of children at age four is closer to maturity. Hence, the abundance of Bifidobacterium significantly decreased in the gut of 4-year-olds, whereas Akkermansia muciniphila increased from 0.14% in 1-year-olds to 4.25% in 4-year-olds. The functional change in gut microbiota is consistent with changes in infant food, as microbiota participating in amino acid and vitamin metabolism were enriched in 1-year-olds, whereas microbiota involved in lipid metabolism increased with age.
- Subjects
GUT microbiome; INFANTS; NUCLEOTIDE sequencing; BACTEROIDETES; BIFIDOBACTERIUM; LIPID metabolism
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, pN.PAG
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-76591-4