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- Title
Regulation of Notch signalling by non-visual β-arrestin.
- Authors
Mukherjee, Ashim; Veraksa, Alexey; Bauer, Andreas; Rosse, Carine; Camonis, Jacques; Artavanis-Tsakonas, Spyros
- Abstract
Signalling activity of the Notch receptor, which plays a fundamental role in metazoan cell fate determination, is controlled at multiple levels. We uncovered a Notch signal-controlling mechanism that depends on the ability of the non-visual β-arrestin, Kurtz (Krz), to influence the degradation and, consequently, the function of the Notch receptor. We identified Krz as a binding partner of a known Notch-pathway modulator, Deltex (Dx), and demonstrated the existence of a trimeric Notch–Dx–Krz protein complex. This complex mediates the degradation of the Notch receptor through a ubiquitination-dependent pathway. Our results establish a novel mode of regulation of Notch signalling and define a new function for non-visual β-arrestins.
- Subjects
NOTCH genes; CELLULAR control mechanisms; BIODEGRADATION; IMMUNOMODULATORS; BIOMOLECULES; PHYSIOLOGICAL control systems; IMMUNOPHARMACOLOGY
- Publication
Nature Cell Biology, 2005, Vol 7, Issue 12, p1091
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb1327