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- Title
NETopathies? Unraveling the Dark Side of Old Diseases through Neutrophils.
- Authors
Mitsios, Alexandros; Arampatzioglou, Athanasios; Arelaki, Stella; Mitroulis, Ioannis; Ritis, Konstantinos; Lewis, Huw; Leppkes, Moritz
- Abstract
Neutrophil extracellular traps (NETs) were initially described as an antimicrobial mechanism of neutrophils. Over the last decade, several lines of evidence support the involvement of NETs in a plethora of pathological conditions. Clinical and experimental data indicate that NET release constitutes a shared mechanism, which is involved in a different degree in various manifestations of non-infectious diseases. Even though the backbone of NETs is similar, there are differences in their protein load in different diseases, which represent alterations in neutrophil protein expression in distinct disorder-specific microenvironments. The characterization of NET protein load in different NET-driven disorders could be of significant diagnostic and/or therapeutic value. Additionally, it will provide further evidence for the role of NETs in disease pathogenesis, and it will enable the characterization of disorders in which neutrophils and NET-dependent inflammation are of critical importance.
- Subjects
NEUTROPHILS; PROTEIN expression; ANTI-infective agents
- Publication
Frontiers in Immunology, 2017, Vol 7, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2016.00678