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- Title
Inflammation-induced cholestasis.
- Authors
Trauner, Michael; Fickert, Peter; Stauber, Rudolf E
- Abstract
Abstract Inflammatory cytokines produced in response to various infectious and non-infectious stimuli are potent inducers of intrahepatic cholestasis (inflammation-induced cholestasis). The cholestatic effect of cytokines results mainly from inhibition of expression and function of hepatocellular transport systems which normally mediate hepatic uptake and biliary excretion of bile salts and various non-bile salt organic anions (e.g. bilirubin). These cytokine effects are reversible and bile secretory function is restored upon disappearance of the inflammatory injury. This review summarizes the clinical, pathophysiological and molecular aspects of inflammation-induced cholestasis. © 1999 Blackwell Science Asia Pty Ltd.
- Subjects
CHOLESTASIS; CYTOKINES; ETIOLOGY of diseases
- Publication
Journal of Gastroenterology & Hepatology, 1999, Vol 14, Issue 10, p946
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1046/j.1440-1746.1999.01982.x