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- Title
Calcifediol improves lipid profile in osteopenicatorvastatin-treated postmenopausal women.
- Authors
Catalano, Antonino; Morabito, Nancy; Basile, Giorgio; Cucinotta, Domenico; Lasco, Antonino
- Abstract
Background Low vitamin D serum levels have been associated with unfavourable lipid profile and poorer response to atorvastatin. Aims of this study were to test the effects of 25-hydroxyvitamin D3 (calcifediol) compared to parental vitamin D3 (cholecalciferol) supplementation on modifications of plasma 25( OH)D levels and lipid profile. Materials and methods Fifty-seven postmenopausal women (aged 59·03 ± 6·73 years) who were at low risk of fracture and with basal plasma 25( OH)D < 30 ng/mL were included if they were on atorvastatin treatment prescribed as appropriate. Recruited women were randomized to receive oral calcifediol or cholecalciferol, both at a dose of 140 μg according to a weekly regimen. Results At baseline, 25( OH)D was negatively associated with BMI ( r = −0·37; P = 0·004), total cholesterol ( r = −0·31; P = 0·01) and LDL-C ( r = −0·32; P = 0·02). After 24 weeks, 25( OH)D increased significantly in both groups ( P < 0·001), although higher levels were obtained with calcifediol as compared with cholecalciferol ( P < 0·001). Only in the calcifediol group, a significant reduction of LDL-C ( P = 0·01) and an increase of HDL-C ( P = 0·02) were obtained, even after adjustment for age, and baseline BMI, 25( OH)D and lipid levels ( P < 0·05). The percentage changes in 25( OH)D levels were associated with the variations of LDL-C ( r = −0·44; P = 0·01) and HDL-C levels ( r = 0·30; P = 0·10). Conclusion Calcifediol administration in osteopenic and dyslipidemic postmenopausal women with low 25( OH)D improves lipid profile when added to an ongoing atorvastatin treatment.
- Subjects
VITAMIN D; OSTEOPENIA; OSTEOPOROSIS in women; ATORVASTATIN; CALCIFEDIOL
- Publication
European Journal of Clinical Investigation, 2015, Vol 45, Issue 2, p144
- ISSN
0014-2972
- Publication type
Article
- DOI
10.1111/eci.12390