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- Title
Low Blood Selenium Concentrations in Critically Ill Children with Systemic Inflammatory Response Syndrome and Respiratory Dysfunction.
- Authors
Young A. Kim; Eun-Ju Ha; Won Kyoung Jhang; Seong Jong Park
- Abstract
Background: Selenium is an essential traceelement with antioxidant and immunological function. We studied the relationship between blood selenium concentrations, systemic inflammatory response syndrome (SIRS) and organ dysfunctions in critically ill children. Methods: This was a retrospective, observational study of the blood selenium concentrations of critically ill children at the time of a pediatric intensive care unit admission. Results: A total of 62 patients with a median age of 18 (5-180) months were included in this study. The mean of blood selenium concentration (μg/dl) was 8.49 ± 2.42. The platelet count (r = -0.378) and PaCO2 (r = -0.403) showed negative correlations with blood selenium concentration, while PaO2/FiO2 (r = 0.359) and PaO2 (r = 0.355) showed positive correlations (p < 0.05, for all variables). Blood selenium concentrations were significantly lower in patients with SIRS than in those patients without SIRS (8.08 ± 2.42 vs. 9.45 ± 2.02, p = 0.011). Patients with severe sepsis and septic shock had showed significantly lower blood selenium concentrations than those without SIRS (7.03 ± 2.73 vs. 9.45 ± 2.02, p = 0.042). Patients with PaO2/FiO2 ⩽ 300 had lower blood selenium concentrations than those with PaO2/FiO2 > 300 (7.90 ± 2.43 vs. 9.54 ± 2.17, p = 0.018). Blood selenium concentrations were significantly lower in patient with PaO2/FiO2 ⩽ 200 than in those with PaO2/FiO2 > 300 (7.64 ± 2.76 vs. 9.54 ± 2.17, p = 0.018). Conclusions: Patients with systemic inflammatory response syndrome or respiratory dysfunction showed significantly low blood selenium concentrations.
- Publication
Korean Journal of Critical Care Medicine, 2013, Vol 28, Issue 2, p86
- ISSN
1229-4802
- Publication type
Article
- DOI
10.4266/kjccm.2013.28.2.86