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- Title
Simultaneous Determination of Volatile Constituents from Acorus tatarinowii Schott in Rat Plasma by Gas Chromatography-Mass Spectrometry with Selective Ion Monitoring and Application in Pharmacokinetic Study.
- Authors
Xue Meng; Xinfeng Zhao; Shixiang Wang; Pu Jia; Yajun Bai; Sha Liao; Xiaohui Zheng
- Abstract
A sensitive and specific gas chromatographic-mass spectrometry with selected ion monitoring (GC-MS/SIM) method has been developed for simultaneous identification and quantification of α-asarone, β-asarone, and methyl eugenol of Acorus tatarinowii Schott in rat plasma. Chromatographic separation was performed on a Restek Rxi-5MS capillary column (30m x 0.32mm x 0.25 µm), using 1-naphthol as internal standard (IS). MS detection of these compounds and IS was performed at m/z 178, 208, 208, and 144. Intra- and interday precisions of all compounds of interest were less than 10%. The recoveries are situated in the range of 92.4-105.2%. Pharmacokinetics of methyl eugenol confirmed to be one-compartment open model, α-asarone and β-asarone was two-compartment open model, respectively. The method will probably be an alternative to simultaneous determination and pharmacokinetic study of volatile ingredients in Acorus tatarinowii Schott.
- Subjects
VOLATILE organic compounds; ACORALES; BLOOD plasma; LABORATORY rats; GAS chromatography/Mass spectrometry (GC-MS); SELECTED ion monitoring; PHARMACOKINETICS
- Publication
Journal of Analytical Methods in Chemistry, 2013, p1
- ISSN
2090-8865
- Publication type
Article
- DOI
10.1155/2013/949830