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- Title
A Case of Mild Encephalopathy with a Reversible Splenial Lesion Associated with G5P[6]Rotavirus Infection.
- Authors
Tsuyoshi Matsuoka; Toshifumi Yodoshi; Misaki Sugai; Masato Hiyane; Takashi Matsuoka; Hideki Akeda; Masaharu Ohfu; Satoshi Komoto; Koki Taniguchi
- Abstract
We report a case of mild encephalopathy with a reversible splenial lesion (MERS) associated with acute gastroenteritis caused by rotavirus (RV) infection. The patient (male, 4 years and 3months old) was admitted to our hospital for diarrhea and afebrile seizures. Head MRI revealed a hyperintense signal in the splenium of the corpus callosum on DWI and a hypointense signal on the ADCmap. After awakening from sedation, the patient's disturbance of consciousness improved. On day 5 after admission of the illness, the patient was discharged from the hospital in a good condition. Electroencephalography on day 2 after admission was normal. On day 8 of admission, head MRI revealed that the splenial lesion had disappeared. RV antigen-positive stools suggested that RV had causedMERS. This RV genotype was considered to be G5P[6]; it may have spread to humans as a strain reassortment through substitution of porcineRVinto humanRVgene segments. This extremely rare genotypewas detected first in Japan and is not covered by existing vaccines; this is the first sample isolated from encephalopathy patients. Few reports have investigated RV genotypes in encephalopathy; we believe that this case is valuable for studying the relationship between genotypes and clinical symptoms.
- Subjects
HYPERTENSIVE encephalopathy; ROTAVIRUS diseases; ELECTROENCEPHALOGRAPHY; CONSCIOUSNESS; GASTROENTERITIS; HOSPITAL admission &; discharge; MAGNETIC resonance imaging
- Publication
Case Reports in Pediatrics, 2013, p1
- ISSN
2090-6803
- Publication type
Article
- DOI
10.1155/2013/197163