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- Title
A Comparative Study of DCMP versus DCcMP Combination Chemotherapy for Adult Acute Leukemia.
- Authors
INAGAKI, JIRO; HORIKOSHI, NOBORU; KATSUHIRO, INOUE; CHINEN, TOSHIAKI; FUJIMOTO, SYUICHI; HOSHINO, AKIRA; OGAWA, MAKOTO; NAKAO, ISAO; KURAISHI, YASUNOBU; MEGURO, SADAYASU; ICHIBA, KENJI; ABE, MASAKAZU
- Abstract
An experimental study using L-1210 mouse leukemia indicated that daunomycin, cyclocytidine, and 6-mercaptopurine (DCcM) combination chemotherapy was more effective than daunomycin, cytosine arabinoside, and 6-mercaptopurine (DCM). Based on these results, a clinical study comparing daunomycin, cytosine arabinoside, 6-mercaptopurine, and predni-solone (DCMP) combination chemotherapy with daunomycin, cyclocytidine, 6-mercaptopurine, and prednisolone (DCcMP) in the treatment of adult acute nonlymphocytic leukemia was conducted. Patients were randomly allocated to receive either regimen. Ten of 15 patients treated with DCMP had complete remission for a median duration of 43 weeks and one had partial remission. Seven of 15 patients treated with DCcMP had complete remission for a median duration of 18 weeks and two had partial remission. The patient characteristics before chemotherapy, the toxicity of the chemotherapeutic regimens and the causes for differences in antitumor activity between the experimental study and the clinical study are discussed.
- Publication
Japanese Journal of Clinical Oncology, 1979, Vol 9, Issue 2, p233
- ISSN
0368-2811
- Publication type
Article