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- Title
Komórki progenitorowe śródbłonka jako nowy marker funkcji endotelium w ocenie ryzyka chorób układu sercowo-naczyniowego.
- Authors
Głowińska-Olszewska, Barbara; Łuczyński, Włodzimierz; Bossowski, Artur
- Abstract
The discovery of endothelial progenitor cells (EPC), over a decade ago, has refuted the previous belief that vasculogenesis only occurs during embryogenesis. The results of several studies revealed altered number and impaired function of EPC in hyperlipidemia, hypertension, diabetes, obesity as well as in rheumatoid arthritis. The population of developmental age is characterized by higher counts of EPC compared to adults. However, among young patients with chronic disorders that affect the vascular system, the number of EPC decreases. The reduced circulating concentration of EPC has become a surrogate marker of endothelial function and has been implicated in the pathogenesis of many vascular diseases. This article aims to review the biology and pathophysiology of EPC in the conditions of cardiovascular risk factors. The potential possibilities of increasing EPC number and function as well as the use of EPC in the treatment of vascular pathology will also be discussed
- Subjects
DISEASE risk factors; METABOLIC disorders; CARBOHYDRATE intolerance; LIPID metabolism disorders; BLOOD lipids
- Publication
Advances in Hygiene & Experimental Medicine / Postepy Higieny i Medycyny Doswiadczalnej, 2011, Vol 65, p8
- ISSN
0032-5449
- Publication type
Article
- DOI
10.5604/17322693.931086