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- Title
INTUBATING CONDITIONS AND CLINICAL ASSESSMENT OF CARDIOVASCULAR EFFECTS BY ANAESTHETIC DRUGS.
- Authors
Patel, Pushpraj; Jain, Anivesh; Harsha, Onteddu Sri; Mishra, Anjeney; Patel, Akhilesh; Patel, Kaveri Shaw
- Abstract
Background: Endotracheal intubation requires the use of medications that are safer than suxamethonium and have the following benefits: early onset, extended duration, steady hemodynamic parameter, minimal adverse effects, and favourable intubating circumstances are necessary to achieve muscle relaxation. Aim: The purpose of this study was to compare the intubating circumstances and cardiovascular effects of rocuronium to those of vecuronium and suxamethonium. Methods: Based on the muscle relaxant used during intubation--Group I received 0.6 mg/kg rocuronium, Group II received 1.5 mg/kg suxamethonium, and Group III received 0.08 mg/kg vecuronium--a total of 120 participants were randomly assigned to 3 groups, each consisting of 40 subjects. 0.2 mg of glycopyrrolate was administered as a premedication, and 4-5 mg/kg of thiopentone sodium 2.5% was utilised as an anaesthetic agent. Vecuronium was also injected intermittently. Fasciculations, cardiovascular reaction, limb movement, coughing, vocal cord movement and position, jaw relaxation, and apnea start were among the parameters evaluated. Results: Group I saw a longer onset than Group II, but a lower one than Group III. Group II had fasciculation while Group I and III did not. Group III had better intubating circumstances. No subject from any group had any complications. Conclusion: The current investigation suggests that, in situations of tracheal intubation involving people who do not require a quick spontaneous breathing return, rocuronium is a safe and effective substitute for suxamethonium. As a result, it can serve as a bridge between suxamethonium and non-depolarizing neuromuscular blocking drugs, making it the perfect neuromuscular agent.
- Subjects
PHARMACODYNAMICS; VOCAL cords; MUSCLE relaxants; TRACHEA intubation; NEUROMUSCULAR blockade; ENDOTRACHEAL suctioning; PREMEDICATION
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 1, p449
- ISSN
0975-3583
- Publication type
Article