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- Title
Vitamin D and Aging: Central Role of Immunocompetence.
- Authors
Carlberg, Carsten; Velleuer, Eunike
- Abstract
The pro-hormone vitamin D3 is an important modulator of both innate and adaptive immunity since its biologically active metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates via the transcription factor VDR (vitamin D receptor) the epigenome and transcriptome of human immune cells and controls in this way the expression of hundreds of vitamin D target genes. Since the myeloid linage of hematopoiesis is epigenetically programmed by VDR in concert with the pioneer factors PU.1 (purine-rich box 1) and CEBPα (CCAAT/enhancer binding protein α), monocytes, macrophages, and dendritic cells are the most vitamin D-sensitive immune cell types. The central role of the immune system in various aging-related diseases suggests that immunocompetence describes not only the ability of an individual to resist pathogens and parasites but also to contest non-communicative diseases and the process of aging itself. In this review, we argue that the individual-specific responsiveness to vitamin D relates to a person's immunocompetence via the epigenetic programming function of VDR and its ligand 1,25(OH)2D3 during hematopoiesis as well as in the periphery. This may provide a mechanism explaining how vitamin D protects against major common diseases and, in parallel, promotes healthy aging.
- Subjects
VITAMIN D metabolism; IMMUNOCOMPETENCE; ACTIVE aging; BIOAVAILABILITY; IMMUNE system; CELL receptors; METABOLISM; VITAMIN D; AGING; GENE expression profiling; HEMATOPOIESIS; EPIGENOMICS
- Publication
Nutrients, 2024, Vol 16, Issue 3, p398
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16030398