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- Title
Change in Urinary Inflammatory Biomarkers and Psychological Health with Gut Microbiome Modulation after Six Months of a Lifestyle Modification Program in Children.
- Authors
Islam, Md Saimul; Page-Hefley, Shyanne; Hernandez, Anne P.; Whelchel, Luke; Crasto, Chiquito; Viator, Whitney; Money, Treyce; Awosile, Babafela; Howard, Noel; Vasylyeva, Tetyana L.
- Abstract
Background: Obesity is a metabolic disorder that negatively impacts the quality of life. Long-term methods such as exercise and low-fat diets can help regulate this health issue, but 93.3 million Americans continue to struggle. Our research investigates if lifestyle changes can affect urinary inflammation markers and psychological aspects through the modification of gut microbiome composition. Methods: Our study included 16 healthy controls with normal BMI as a comparison group and 22 overweight/obese (OW/OB) adolescents. We collected demographic, clinical, psychological, stool, and urine sample data at enrollment and six months after implementing lifestyle modifications. Bacterial genomic data and inflammatory markers in these samples were analyzed. Results: The lifestyle interventions were associated with decreased inflammation and enhanced mental health among overweight teens. We observed differences in bacterial community compositions between healthy participants and those who underwent treatment, including exercise and dietary habit adjustments, although there was no significant change in bacterial species richness. Mental health correlated with gut microbiota compositions without any demographic influences. The research also uncovered connections between inflammatory markers, psychological factors, and gut microbiota phyla through carbohydrate metabolism alterations. Conclusion: Our findings demonstrate that lifestyle modifications are associated with improved mental health and a reduction in inflammation in overweight adolescents by adjusting the gut microbiota composition.
- Subjects
URINARY tract infection diagnosis; OBESITY risk factors; BIOMARKERS; EVALUATION of human services programs; GUT microbiome; TIME; CYSTITIS; COMPARATIVE studies; HEALTH behavior; DESCRIPTIVE statistics; RESEARCH funding; PSYCHOLOGY of the sick; BODY mass index; ROUTINE diagnostic tests; BEHAVIOR modification; DISEASE risk factors; PSYCHOSOCIAL factors; CHILDREN
- Publication
Nutrients, 2023, Vol 15, Issue 19, p4243
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15194243