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- Title
Impact of a Prenatal Vitamin D Supplementation Program on Vitamin D Deficiency, Rickets and Early Childhood Caries in an Alaska Native Population.
- Authors
Singleton, Rosalyn J.; Day, Gretchen M.; Thomas, Timothy K.; Klejka, Joseph A.; Desnoyers, Christine A.; McIntyre, Melanie N. P.; Compton, David M.; Thummel, Kenneth E.; Schroth, Robert J.; Ward, Leanne M.; Lenaker, Dane C.; Lescher, Rachel K.; McLaughlin, Joseph B.
- Abstract
Background: Early childhood rickets increased in Alaska Native children after decreases in vitamin D-rich subsistence diet in childbearing-aged women. We evaluated the impact of routine prenatal vitamin D supplementation initiated in Alaska's Yukon Kuskokwim Delta in Fall 2016. Methods: We queried electronic health records of prenatal women with 25(OH) vitamin D testing during the period 2015–2019. We evaluated 25(OH)D concentrations, vitamin D3 supplement refills, and decayed, missing, and filled teeth (dmft) scores and rickets in offspring. Results: Mean 25(OH)D concentrations increased 36.5% from pre- to post-supplementation; the percentage with deficient 25(OH)D decreased by 66.4%. Women with ≥ 60 vitamin D3 refill days had higher late pregnancy 25(OH)D concentrations than those with no refill days (p < 0.0001). Women with late pregnancy insufficient 25(OH)D concentrations had offspring with higher dmft scores than those with sufficient 25(OH)D (RR 1.3, p < 0.0001). Three children were diagnosed with nutritional rickets during the period 2001–2021, and none after 2017. Conclusions: These findings suggest that prenatal vitamin D supplementation can improve childhood outcomes in high-risk populations with high rates of rickets.
- Subjects
ALASKA; CAVITY prevention; RICKETS prevention; ALASKA Natives; CALCITRIOL; NUTRITIONAL requirements; PREGNANT women; DIETARY supplements; TREATMENT effectiveness; MATERNAL age; VITAMIN D deficiency; ELECTRONIC health records; CHILDREN; PREGNANCY
- Publication
Nutrients, 2022, Vol 14, Issue 19, p3935
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14193935