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- Title
Role of Citrate in Pathophysiology and Medical Management of Bone Diseases.
- Authors
Granchi, Donatella; Baldini, Nicola; Ulivieri, Fabio Massimo; Caudarella, Renata
- Abstract
Citrate is an intermediate in the "Tricarboxylic Acid Cycle" and is used by all aerobic organisms to produce usable chemical energy. It is a derivative of citric acid, a weak organic acid which can be introduced with diet since it naturally exists in a variety of fruits and vegetables, and can be consumed as a dietary supplement. The close association between this compound and bone was pointed out for the first time by Dickens in 1941, who showed that approximately 90% of the citrate bulk of the human body resides in mineralised tissues. Since then, the number of published articles has increased exponentially, and considerable progress in understanding how citrate is involved in bone metabolism has been made. This review summarises current knowledge regarding the role of citrate in the pathophysiology and medical management of bone disorders.
- Subjects
TREATMENT of bone diseases; BONE metabolism; BONE remodeling; BONE diseases; CITRATES; DIETARY supplements; FRUIT; VEGETABLES; BONE density
- Publication
Nutrients, 2019, Vol 11, Issue 11, p2576
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11112576