We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Intestinal Phosphorus Absorption in Chronic Kidney Disease.
- Authors
Stremke, Elizabeth R.; Hill Gallant, Kathleen M.
- Abstract
Chronic kidney disease (CKD) affects approximately 10% of adults worldwide. Dysregulation of phosphorus homeostasis which occurs in CKD leads to development of CKD-Mineral Bone Disorder (CKD-MBD) and contributes to increased morbidity and mortality in these patients. Phosphorus is regulated by multiple hormones (parathyroid hormone (PTH), 1,25-dihyxdroxyvitamin D (1,25D), and fibroblast growth factor 23 (FGF23)) and tissues (kidney, intestine, parathyroid glands, and bone) to maintain homeostasis. In health, the kidneys are the major site of regulation for phosphorus homeostasis. However, as kidney function declines, the ability of the kidneys to adequately excrete phosphorus is reduced. The hormonal changes that occur with CKD would suggest that the intestine should compensate for impaired renal phosphorus excretion by reducing fractional intestinal phosphorus absorption. However, limited studies in CKD animal models and patients with CKD suggest that there may be a break in this homeostatic response where the intestine fails to compensate. As many existing therapies for phosphate management in CKD are aimed at reducing absolute intestinal phosphorus absorption, better understanding of the factors that influence fractional and absolute absorption, the mechanism by which intestinal phosphate absorption occurs, and how CKD modifies these is a much-needed area of study.
- Subjects
TREATMENT of chronic kidney failure; RICKETS treatment; HORMONE metabolism; CHRONIC kidney failure; DISEASES; GROWTH factors; HOMEOSTASIS; INTESTINAL absorption; PARATHYROID glands; PARATHYROID hormone; PHOSPHORUS; RICKETS; CALCITRIOL
- Publication
Nutrients, 2018, Vol 10, Issue 10, p1364
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10101364